mgm4858am集团

    mgm4858am集团 /诊断试剂 /热门肿瘤标志物 /TMB /bTMB-P1 (22.91) Reference Standard

    bTMB-P1 (22.91) Reference Standard

    CBP80001-10

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    I. Background

    Tumor mutational burden (TMB) shows great promise as a biomarker for immuno-oncology (I-O) therapy response, but progress is hindered by the lack of a standardized TMB measurement by targeted NGS panels, and an absence of TMB reference materials. 

     

    Sample ID

    Cat.No.

    Format

    Background

    Assay

    Comments

    DC20030079

    CBP80001-10N

    gDNA

    B lymphoblast, Female

    500x WES

    Same individual

    DC20030078

    CBP80001-10T

    ctDNA (Enzymatic digestion)

    stage 4, adenocarcinoma Lung, Female

    IDT xGenExome Research Panel v1.0捕获,Target Region 39M, Probe Region 51M,CDS Region 33.52M;
    HiSeq X-TEN,af选择0.02 cut off,再过滤。

    DC20030078 is 100% Tumor sample and DC20030079 is 100% Normal sample.

     

     

     

    Cut off =1%

    Cut off =2%

    Cut off =3%

    Cut off =4%

    Cut off =5%

    Mutation Number

    769

    768

    734

    720

    713

    TMB value

    22.91

    22.91

    21.90

    21.48

    21.27

    Data Download

    DC20030078.filter.0.0.01.tag.maf

    DC20030078.filter.0.0.02.tag.maf

    DC20030078.filter.0.0.03.tag.maf

    DC20030078.filter.0.0.04.tag.maf

    DC20030078.filter.0.0.05.tag.maf

     

     
     
     
     

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